Subjects were studied in the upright and supine position, during acute zero gravity (parabolic flight) and prolonged simulated microgravity (6 deg head-down tilt bedrest). ICP was assessed by placing a fluid-filled 25 gauge butterfly needle into the Ommaya reservoir.
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We recruited five men and three women who had an Ommaya reservoir inserted for the delivery of prophylactic CNS chemotherapy, but were free of their malignant disease for at least 1 year. This syndrome is considered the most mission-critical medical problem identified in the past decade of manned spaceflight. Thus, over 24 h in zero gravity, pressure in the brain is slightly above that observed on Earth, which may explain remodelling of the eye in astronauts.Īstronauts have recently been discovered to have impaired vision, with a presentation that resembles syndromes of elevated intracranial pressure (ICP). This being said, intracranial pressure is not reduced to the levels observed in the 90 deg seated upright posture on Earth.In contrast to prevailing theory, we observed that microgravity reduces central venous and intracranial pressure. Gravity has a profound effect on fluid distribution and pressure within the human circulation.
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